Allopurinol is a well-known prescription medication and chemical compound widely used in managing uric acid-related conditions. If you’re exploring its health applications, ideal dosing protocols, side effects, and how to source it in bulk or as a raw ingredient, this comprehensive guide is designed for you.
✅ What is Allopurinol?
Allopurinol is a xanthine oxidase inhibitor primarily used to lower uric acid levels in the blood. It’s commonly prescribed for conditions like gout, kidney stones, and hyperuricemia caused by chemotherapy. Its chemical name is 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, and it works by inhibiting the enzyme xanthine oxidase, which is responsible for converting hypoxanthine to uric acid.
- CAS Number: 315-30-0
- Molecular Formula: C5H4N4O
- Molecular Weight: 136.11 g/mol
🔬 Ingredients & Composition
Allopurinol raw powder is a white to off-white crystalline compound, typically synthesized in laboratory settings. Pharmaceutical formulations may contain excipients like lactose, starch, and magnesium stearate, depending on the brand.
💊 Health Benefits of Allopurinol
- Reduces Gout Attacks: By lowering uric acid levels, it prevents painful flare-ups.
- Prevents Kidney Stones: Minimizes the risk of uric acid crystallization in the kidneys.
- Supports Chemotherapy Patients: Manages uric acid build-up due to cell breakdown.
- Improves Renal Health: Protects kidneys from uric acid-induced damage.
- Enhances Quality of Life: Reduces joint inflammation and chronic pain.
- Prevents Tophus Formation: Long-term use dissolves tophi (hard uric acid deposits).
- Lowers Serum Uric Acid in Cardiovascular Patients: Emerging studies show benefits for heart health.
- Reduces Need for NSAIDs: Lower flare frequency reduces dependency on anti-inflammatory drugs.
- Can Be Used in Genetic Disorders: Sometimes used in Lesch-Nyhan syndrome under medical supervision.
- Helps in Tumor Lysis Syndrome: Reduces risk during cancer treatment.
📈 How Effective is Allopurinol?
Clinical studies show that serum uric acid levels decrease significantly within 2–3 weeks of daily use. Gout flares may still occur during early therapy but typically reduce in frequency and severity over time. Long-term use has been proven effective in preventing complications like joint damage and kidney disease.
🧪 How to Take Allopurinol? Dosage Guidelines
- Initial Dose: 100 mg once daily.
- Maintenance Dose: 200–300 mg daily (mild cases), up to 400–600 mg (moderate-severe cases).
- Maximum Dose: 800 mg/day under strict medical supervision.
Important: Always start with a low dose and gradually increase to avoid gout flare-ups. Adequate hydration is crucial to reduce the risk of kidney stones.
⚠️ Side Effects of Allopurinol
While Allopurinol is generally well-tolerated, some users may experience:
- Skin rashes (can be severe)
- Nausea or vomiting
- Liver enzyme changes
- Kidney dysfunction
- Hypersensitivity syndrome (rare but serious)
Seek immediate medical attention for rash, fever, swollen glands, or difficulty breathing.
📋 Who Should Use It?
- Individuals with chronic gout
- People prone to uric acid kidney stones
- Cancer patients undergoing chemotherapy
- Patients with recurrent hyperuricemia
Not suitable for: Pregnant or breastfeeding women, patients with severe liver or kidney issues unless prescribed, or those with known hypersensitivity.
❓ People Also Ask
Q: Can Allopurinol cure gout?
A: It doesn’t cure gout but prevents future attacks by lowering uric acid levels.
Q: How long should I take Allopurinol?
A: It is typically used long-term, often for life, to maintain normal uric acid levels.
Q: Can I drink alcohol while taking Allopurinol?
A: It’s best to avoid alcohol, as it can increase uric acid and reduce Allopurinol’s effectiveness.
Q: Is Allopurinol an anti-inflammatory?
A: No. It prevents uric acid formation, whereas anti-inflammatories treat acute flare symptoms.
📦 Where Can I Buy Allopurinol Raw Material?
If you’re looking for high-purity Allopurinol powder as a raw ingredient for pharmaceutical or supplement manufacturing, consider the following trusted supplier:
🧪 Shaanxi Zhonghong Investment Technology Co., Ltd.
- Website: https://aiherba.com
- Email:
They specialize in natural plant extracts and pharmaceutical raw materials with strict GMP and ISO-compliant standards.
⭐ Featured Summary
Allopurinol is a clinically validated xanthine oxidase inhibitor used to manage gout, hyperuricemia, and uric acid kidney stones. With proven efficacy and multiple applications, it remains a cornerstone in uric acid-lowering therapy. For raw material sourcing, Shaanxi Zhonghong offers bulk high-purity powder with global shipping and technical support.
💬 User Reviews
James L. – USA
“After six months on Allopurinol, my gout attacks stopped completely. No more joint pain!”
Wei Chen – Supplier Client
“We use Zhonghong’s Allopurinol in our capsule line. Quality and consistency are top-notch.”
📚 References
- Richette, P., & Bardin, T. (2010). Gout. The Lancet, 375(9711), 318–328.
- Stamp, L. K., et al. (2017). The optimal use of Allopurinol: when, how, and why? Therapeutic Advances in Musculoskeletal Disease, 9(2), 43–59.
- British National Formulary (BNF) – Allopurinol Monograph
- FDA Label – Allopurinol Tablets USP
- MedlinePlus – Allopurinol (Oral Route)