Centella Asiatica Serum: The Botanical Powerhouse for Skin Regeneration
1. What is Centella Asiatica Serum?
Centella Asiatica Serum, derived from the leaves of Centella asiatica (Gotu kola), is a concentrated botanical formulation renowned for its exceptional skin – healing and regenerative properties. Rich in bioactive compounds—including asiaticoside (5–10%), madecassoside (3–8%), and centellic acid—it addresses inflammation, promotes collagen synthesis, and strengthens the skin barrier. Our serum is extracted using ultrasonic – assisted technology to preserve thermolabile actives, delivering a pH – balanced (5.5–6.5) formula with 98% purity, ideal for sensitive, acne – prone, and aging skin.
2. Company Introduction
2.1 A 28 – Year Legacy in Botanical Excellence
Shaanxi Zhonghong Investment Technology Co., Ltd. is a leading high – tech enterprise specializing in the extraction, purification, and application of plant – based bioactives. For 28 years, we have integrated agile R&D, university collaborations, and global manufacturing to serve chemistry, materials, and life sciences industries. Our portfolio includes natural extracts, cosmetic raw materials, and pharmaceutical intermediates, all backed by proprietary technologies and strict quality systems.
2.2 Research and Development Prowess
- University Partnerships: Collaborations with 5 top – tier universities have yielded over 20 patents, including our patented enzyme – mediated extraction for centella glycosides, increasing asiaticoside yield by 25%.
- Exclusive Compound Library: Our global – unique library houses 10,000+ plant compounds, enabling in – depth research into centella’s wound – healing mechanisms and formulation optimization.
- State – of – the – Art Facilities: Equipped with HPLC, NMR, and ICP – MS, we achieve a purity standard 20% higher than industry averages, ensuring consistent potency and safety for cosmetic and pharmaceutical use.
2.3 Global Supply Network
We distribute centella asiatica serum to 80+ countries across Asia, Europe, and the Americas, providing customized solutions to skincare brands, dermatological clinics, and nutraceutical companies. Our vertically integrated supply chain ensures traceability from farm to formulation, with GMP – certified production and compliance with EU Cosmetics Regulation and USP standards.
3. Centella asiatica serumProduct Source
3.1 Botanical Origin and Sourcing
Centella asiatica thrives in tropical wetlands of India, Southeast Asia, and Madagascar. We source leaves from USDA Organic and EU Organic certified farms in Kerala, India, where the plant grows in nutrient – rich, pesticide – free environments. Leaves are harvested at the flowering stage (6–8 months post – planting) to maximize glycoside content (total triterpenoids ≥15%).
3.2 Centella asiatica serum Extraction Process
- Leaf Harvesting: Hand – picked leaves are dried at ≤40°C to preserve bioactives, then milled into a fine powder (100 mesh).
- Ultrasonic – Assisted Extraction: Mixed with food – grade ethanol (50–70%) and subjected to ultrasonic waves (40 kHz, 30°C) to disrupt cell walls, increasing extraction efficiency by 40% compared to conventional methods.
- Chromatographic Purification: Crude extract is purified via silica gel column chromatography to isolate asiaticoside and madecassoside, achieving ≥98% purity (HPLC – validated).
- Formulation: Blended with hyaluronic acid and glycerin for optimal skin penetration, or supplied as a raw concentrate for industrial clients.
4. Health Benefits and Mechanisms
4.1 Skin Regeneration & Wound Healing
- Collagen Synthesis: Asiaticoside stimulates fibroblasts to produce collagen type I/III by 60% in 14 days (Journal of Dermatological Science, 2022), reducing scar visibility and improving skin elasticity.
- Epithelialization: Accelerates wound closure by 30% in preclinical models, promoting faster healing for acne scars, surgical wounds, and burns.
4.2 Anti – Inflammatory Power
- NF – κB Inhibition: Suppresses pro – inflammatory cytokines (IL – 6, TNF – α) by 45%, ideal for calming rosacea, eczema, and post – procedure inflammation (Phytomedicine, 2021).
- Skin Barrier Protection: Enhances filaggrin synthesis, reducing transepidermal water loss by 22% and improving hydration for dry, sensitive skin.
4.3 Antioxidant Defense
- Free Radical Scavenging: Neutralizes DPPH radicals with an IC50 of 15 μg/mL, protecting skin from UVB – induced oxidative stress and premature aging.
5. Usage Guidelines
5.1 Cosmetic Application
- Concentration: 2–5% in serums, creams, and sheet masks; 1–3% in cleansers and toners.
- Application: Apply 2–3 drops to clean skin AM/PM, gently massaging into target areas (face, neck, scars). Pair with niacinamide for enhanced barrier repair or vitamin C for antioxidant synergy.
- Suitable Skin Types: All skin types, especially sensitive, acne – prone, and post – inflammatory hyperpigmentation (PIH) skin.
5.2 Professional Use
- Dermocosmetics: Used in clinical formulations for post – laser rejuvenation, microdermabrasion recovery, and chronic wound care.
- Sunscreen Additive: Enhances UV protection by reducing inflammation – induced pigmentation when combined with zinc oxide.
5.3 Storage
Store in amber glass bottles at 15–25°C, away from direct light. Shelf life: 24 months unopened; 12 months after opening.
6. Precautions
- Photosensitivity: No known photosensitization, but always follow with sunscreen for daytime use.
- Allergy Testing: Perform a patch test for plant allergy history; discontinue if redness/itching occurs.
- Pregnancy/Lactation: Generally safe for topical use, but consult a dermatologist for personalized advice.
7. Product Specifications
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Project
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Name
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Indicator
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Detection Method
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|
Pesticide Residues
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Chlorpyrifos
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< 0.01 ppm
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GC – MS (Gas Chromatography – Mass Spectrometry)
|
|
Carbendazim
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< 0.005 ppm
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GC – MS/MS
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|
|
Heavy Metals
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Lead (Pb)
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< 0.1 ppm
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ICP – MS (Inductively Coupled Plasma – MS)
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|
Cadmium (Cd)
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< 0.05 ppm
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ICP – MS
|
|
|
Microbial Safety
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Total Plate Count
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< 1000 CFU/g
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Agar Plate Counting
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E. coli
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Absent
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Most Probable Number Test
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|
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Staphylococcus aureus
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Absent
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PCR – Based Detection
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8. Production Process
8.1 Raw Material QC
Leaves are tested for asiaticoside/madecassoside content (HPLC), with only batches ≥18% total triterpenoids approved for extraction.
8.2 Extraction & Purification
- Ultrasonic Extraction: 3 – stage process with ethanol:water (60:40 v/v) at 30°C for 60 minutes, yielding a crude extract with 85% glycoside retention.
- Winterization: Cold – filtered to remove waxes, improving solubility in aqueous formulations.
- Molecular Distillation: Further purifies to ≥98% asiaticoside/madecassoside, confirmed by NMR for structural integrity.
8.3 Formulation & Testing
- Stability Testing: Accelerated aging at 40°C/75% RH for 4 weeks shows <3% degradation of active compounds.
- pH Adjustment: Buffered to 5.5–6.5 to match skin’s acid mantle, reducing irritation risk.
9. Application Scenarios
9.1 Cosmetic Industry
- Anti – Aging Products: Serums and creams for wrinkle reduction, skin firming, and dark spot correction.
- Acne & Sensitivity Care: Toners and spot treatments to calm inflammation, reduce post – acne redness, and prevent scarring.
- Baby Care: Gentle formulations for eczema – prone infant skin, leveraging centella’s soothing properties.
9.2 Pharmaceutical Industry
- Wound Dressings: Incorporated into hydrogels and ointments for diabetic ulcers and burn recovery.
- Oral Supplements: Capsules for internal inflammation management (under clinical evaluation for IBS and arthritis).
9.3 Functional Foods
- Nutraceuticals: Tablets and powders for skin health support, often combined with collagen and hyaluronic acid.
10. Quality Control
Quality control at Shaanxi Zhonghong ensures centella asiatica serum meets the highest standards:
- Raw Material Traceability: Each leaf batch is tracked via blockchain, with COA verifying organic certification and pesticide residue testing (200+ analytes via GC – MS).
- Potency Assurance: HPLC quantifies asiaticoside (5–10%) and madecassoside (3–8%), ensuring label claims are met with ±5% accuracy.
- Contaminant Testing: ICP – MS confirms heavy metals are 50% below USP limits (Pb < 0.1 ppm, As < 0.05 ppm), while PCR – based methods ensure microbial safety (pathogens absent in 100% of batches).
- Formulation Validation: Rheological tests measure viscosity and pH stability, ensuring compatibility with emulsions and serums. Accelerated stability studies (ICH Q1A) validate 24 – month shelf life with <5% active degradation.
- Third – Party Certification: Independent labs verify purity and safety, with compliance to EU Cosmetics Regulation (EC 1223/2009) and ISO 22716:2007 (Cosmetic GMP).
Our 20% purity premium over industry norms ensures consistent efficacy, making our centella asiatica serum a benchmark for botanical skin care.
11. Packaging and Logistics
11.1 Packaging
- Bulk Orders: 1kg, 5kg, or 25kg food – grade stainless steel drums with nitrogen flushing to prevent oxidation.
- Retail: 30mL, 50mL, or 100mL amber glass dropper bottles with UV – resistant coating, ideal for direct consumer use.
11.2 Logistics
- Global Shipping: Fedex/DHL Express (3–7 days) for samples and small orders; sea freight (20–30 days) for bulk quantities.
- Customs Support: We provide all necessary documentation—COA, MSDS, organic certificates, and stability data—to facilitate clearance in target markets.
12. Research and Innovation
12.1 Mechanistic Insights
- MMP Inhibition: Asiaticoside suppresses matrix metalloproteinase – 1 (MMP – 1) by 40%, reducing collagen degradation in photoaged skin (International Journal of Molecular Sciences, 2023).
- Gut – Skin Axis: Preclinical studies link oral centella intake to reduced skin inflammation via microbiome modulation, a frontier in nutraceutical research.
12.2 Technological Innovations
- Nanoliposomal Delivery: Developed a nanoencapsulated serum with 2x higher transdermal absorption, enhancing asiaticoside penetration by 35% (Journal of Controlled Release, 2022).
- Sustainable Extraction: Patented a water – based extraction process reducing ethanol usage by 60%, aligning with global green chemistry initiatives.
12.3 Challenges and Frontiers
- Stability in Aqueous Systems: Ongoing research to improve glycoside solubility in low – alcohol formulations.
- Chronic Disease Applications: Phase II trials evaluating oral centella for rheumatoid arthritis and ulcerative colitis, expanding its therapeutic potential.
13. FAQ
13.1 Where to Purchase Centella Asiatica Serum?
- Bulk Inquiries: Contact us at liaodaohai@gmail.com for customized quotes, samples, and technical data sheets.
- Distribution Network: Find our products through global partners listed on www.aiherbm.com/Centella-Asiatica-Serum.
13.2 Is It Safe for Sensitive Skin?
Yes—clinical trials show 92% user satisfaction in sensitive skin groups, with no significant irritation reported (Dermatitis, 2021).
13.3 Can It Be Used with Retinol?
Yes, but wait 1 hour between applications to avoid pH interference. Centella’s anti – inflammatory effects complement retinol’s exfoliating benefits.
13.4 How Soon Will I See Results?
Visible improvements in redness and texture may occur within 2–4 weeks; scar reduction takes 8–12 weeks with consistent use.
14. Conclusion
Centella asiatica serum stands as a botanical marvel, combining ancient healing wisdom with modern science to address diverse skin concerns. Shaanxi Zhonghong Investment Technology Co., Ltd. leverages 28 years of extraction expertise and technological innovation to deliver a serum that sets the standard for purity, efficacy, and sustainability. As the global demand for natural skin solutions grows, our commitment to quality and innovation ensures we remain the preferred partner for centella – based formulations worldwide.
15. References
- “Centella Asiatica in Dermatology: A Review of Its Pharmacological Properties and Clinical Applications.” Journal of Cosmetic Dermatology, 2020.
- EU Cosmetics Regulation (EC) No 1223/2009: Safety Assessment of Cosmetic Ingredients.
- “Asiaticoside Promotes Skin Regeneration by Activating TGF – β/Smad Signaling Pathway.” International Journal of Molecular Medicine, 2022.
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